Multifunctional biological nanostructures for cancer treatment
Background: Cancer is a serious threat to human health, the current treatment methods still have many limitations, such as poor drug targeting, side effects, high drug resistance. In order to improve the efficiency and safety of cancer therapy, multifunctional biological nanostructures, as a new anticancer drug carrier, have attracted extensive attention and research in recent years. Multifunctional biological nanostructures refer to nanomaterials with specific morphology and size that are self-assembled or synthesized by biomolecules (such as polysaccharides, nucleic acids, peptides, proteins, etc.). They have the characteristics of good biocompatibility, strong supramolecular properties, high targeting, sensitive responsiveness, and strong programmable ability. Using these features, a variety of anti-cancer functions (such as targeted delivery, sequential targeting, stimulus responsiveness, therapeutics, combination therapy, etc.) can be integrated in a nanosystem to achieve accurate and intelligent cancer treatment.
Project Description: This project aims to develop a multi-functional tumor diagnosis and treatment platform based on DNA nanostructure for early diagnosis and combined treatment of tumors. DNA nanostructure refers to the design and construction of DNA molecular assembly with specific shape and function at nanometer scale through the principle of complementary base pairing of DNA molecules. DNA nanostructures have precise designability, addressability and programmability, and can achieve a variety of morphological and functional regulation by changing DNA sequence and topology. This project will use these advantages of DNA nanostructure to design a multifunctional tumor diagnosis and treatment platform with the following functions:
Tumor targeting: By modifying tumor specific ligands (such as folic acid, antibodies, etc.) to achieve efficient targeting of tumor cells;
Tumor imaging: Through the modification of imaging probes (such as fluorescent dyes, nuclides, etc.) to achieve non-invasive imaging diagnosis of tumors;
Tumor therapy: Through modifying drug molecules (such as chemotherapy drugs, gene drugs, etc.) to achieve effective treatment of tumors;
Tumor response: Sensitive response to tumor microenvironment (such as pH value, enzyme activity, etc.) can be achieved by designing response elements (such as logic gates, switches, etc.) to achieve controlled drug release;
Tumor feedback: Through the design of feedback mechanisms (such as signal amplification, signal conversion, etc.) to achieve real-time monitoring and regulation of treatment effects.
Project content:
Design and synthesize DNA nanostructures with the above functions, and characterize and evaluate them.
To evaluate the biocompatibility and safety of DNA nanostructures in vitro and in vivo;
To evaluate tumor targeting, imaging performance and therapeutic efficacy of DNA nanostructures in vitro and in vivo;
To evaluate tumor responsiveness and feedback mechanisms of DNA nanostructures in vivo;
To explore the application potential of DNA nanostructures in early cancer diagnosis and combination therapy.
Topic innovation:
By utilizing the designability and programmability of DNA nanostructures, the integration and collaboration of various anticancer functions are realized to improve the precision and intelligence of cancer treatment.
The addressability and responsiveness of DNA nanostructures are utilized to achieve controlled drug release and real-time monitoring and regulation of therapeutic effects, improving the efficiency and safety of cancer treatment.
Using the versatility of DNA nanostructure, the early diagnosis and combined therapy of cancer can be realized, and the comprehensive effect of cancer treatment can be improved.
Project Description: This project aims to develop a multi-functional tumor diagnosis and treatment platform based on DNA nanostructure for early diagnosis and combined treatment of tumors. DNA nanostructure refers to the design and construction of DNA molecular assembly with specific shape and function at nanometer scale through the principle of complementary base pairing of DNA molecules. DNA nanostructures have precise designability, addressability and programmability, and can achieve a variety of morphological and functional regulation by changing DNA sequence and topology. This project will use these advantages of DNA nanostructure to design a multifunctional tumor diagnosis and treatment platform with the following functions:
Tumor targeting: By modifying tumor specific ligands (such as folic acid, antibodies, etc.) to achieve efficient targeting of tumor cells;
Tumor imaging: Through the modification of imaging probes (such as fluorescent dyes, nuclides, etc.) to achieve non-invasive imaging diagnosis of tumors;
Tumor therapy: Through modifying drug molecules (such as chemotherapy drugs, gene drugs, etc.) to achieve effective treatment of tumors;
Tumor response: Sensitive response to tumor microenvironment (such as pH value, enzyme activity, etc.) can be achieved by designing response elements (such as logic gates, switches, etc.) to achieve controlled drug release;
Tumor feedback: Through the design of feedback mechanisms (such as signal amplification, signal conversion, etc.) to achieve real-time monitoring and regulation of treatment effects.
Project content:
Design and synthesize DNA nanostructures with the above functions, and characterize and evaluate them.
To evaluate the biocompatibility and safety of DNA nanostructures in vitro and in vivo;
To evaluate tumor targeting, imaging performance and therapeutic efficacy of DNA nanostructures in vitro and in vivo;
To evaluate tumor responsiveness and feedback mechanisms of DNA nanostructures in vivo;
To explore the application potential of DNA nanostructures in early cancer diagnosis and combination therapy.
Topic innovation:
By utilizing the designability and programmability of DNA nanostructures, the integration and collaboration of various anticancer functions are realized to improve the precision and intelligence of cancer treatment.
The addressability and responsiveness of DNA nanostructures are utilized to achieve controlled drug release and real-time monitoring and regulation of therapeutic effects, improving the efficiency and safety of cancer treatment.
Using the versatility of DNA nanostructure, the early diagnosis and combined therapy of cancer can be realized, and the comprehensive effect of cancer treatment can be improved.
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