Biomedicine Microbiome based immune regulation and disease treatment
Project background:
The microbiome refers to the sum total of microorganisms (such as bacteria, fungi, viruses, etc.) living inside and outside the human body or other organisms that interact with the host and affect the physiological function and health status of the host. In recent years, microbiome studies have revealed the close relationship between the microbiome and the immune system, and found that the microbiome can regulate the development, differentiation, activation and function of immune cells through various mechanisms, so as to participate in the maintenance of immune balance and the regulation of immune response. The imbalance or abnormality of the microbiome is related to the occurrence and development of a variety of immune-related diseases (such as infectious diseases, autoimmune diseases, tumors, allergic diseases, etc.). Therefore, by regulating or changing the structure and function of the microbiome, it is expected to provide new strategies and means for the prevention and treatment of these diseases.
Project curriculum design research topics:
Microbiome based immune regulation and disease treatment
Research purpose:
To explore the molecular mechanisms and signaling pathways of the interaction between microbiome and immune system, and to provide theoretical basis and molecular targets for microbiome regulation of immune-related diseases. To develop novel microbiome intervention techniques and formulations to provide new methods and means for the treatment of immune-related diseases. To evaluate the efficacy and safety of microbiome intervention in the treatment of immune-related diseases, and to provide scientific basis and optimization plan for the clinical application of microbiome intervention.
Research content:
1. The relationship between microbiome and infectious diseases and intervention strategies. This content aims to analyze the impact of different types of infectious diseases (such as bacterial infections, fungal infections, parasitic infections, etc.) on the host microbiome, as well as the resistance of the host microbiome to infectious pathogens, screen functional strains or engineered bacteria that have antibacterial or enhanced immunity against infections, and evaluate their efficacy in the treatment of infectious diseases.
2. The relationship between microbiome and autoimmune diseases and intervention strategies. This content aims to analyze the influence of different types of autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, etc.) on the host microbiome, as well as the regulatory role of the host microbiome on autoimmunity tolerance and autoimmune response, and screen functional strains or engineered bacteria with anti-inflammatory or immunotolerant ability. And to evaluate the therapeutic effect on autoimmune diseases.
3. The relationship between microbiome and tumor and intervention strategies. This content aims to analyze the influence of different types of tumors (such as digestive tract tumors, lung cancer, breast cancer, etc.) on the host microbiome, as well as the promotion or inhibition of the host microbiome on the occurrence, development and metastasis of tumors, screen functional strains or engineered bacteria with anti-tumor or synergistic anti-tumor immunity, and evaluate their efficacy in tumor therapy.
4. Relationship between microbiome and allergic diseases and intervention strategies. This content aims to analyze the influence of different types of allergic diseases (such as asthma, allergic rhinitis, eczema, etc.) on the host microbiome, as well as the regulatory role of the host microbiome on the allergen-induced Th2 immune response, and screen functional strains or engineered bacteria with the ability to inhibit Th2 immunity or induce Th1/Th17 immune balance. And to evaluate the therapeutic effect on allergic diseases.
Expected results:
To establish a microbiome database of patients with different types of immune-related diseases and healthy people, and reveal the molecular mechanisms and signaling pathways of microbiome interaction with the immune system.
Functional strains or engineered bacteria with immunomodulatory ability were screened to construct novel microbiome intervention techniques and preparations.
To confirm the efficacy and safety of microbiome intervention in the treatment of immune-related diseases through animal models and clinical trials, and to explore the synergistic effect and optimization of microbiome intervention with other therapeutic means.
Project highlights:
1. Adopt multi-omics methods (such as metagenomics, transcriptomics, metabolomics, etc.) to systematically analyze the microbiome characteristics of patients with different types of immune-related diseases and healthy people, and reveal the molecular mechanisms and signaling pathways of the interaction between the microbiome and the immune system.
2. Optimize and modify the microbiome to enhance its immunomodulatory ability and provide new microbial preparations for the treatment of immune-related diseases by means of functional strain screening, fecal transplanting and construction of engineered bacteria.
3. Use animal models and clinical trials to evaluate the efficacy and safety of microbiome intervention in the treatment of immune-related diseases, and explore the synergistic effect and optimization of microbiome intervention with other therapeutic means (such as drugs, chemoradiotherapy, immunotherapy, etc.).
The microbiome refers to the sum total of microorganisms (such as bacteria, fungi, viruses, etc.) living inside and outside the human body or other organisms that interact with the host and affect the physiological function and health status of the host. In recent years, microbiome studies have revealed the close relationship between the microbiome and the immune system, and found that the microbiome can regulate the development, differentiation, activation and function of immune cells through various mechanisms, so as to participate in the maintenance of immune balance and the regulation of immune response. The imbalance or abnormality of the microbiome is related to the occurrence and development of a variety of immune-related diseases (such as infectious diseases, autoimmune diseases, tumors, allergic diseases, etc.). Therefore, by regulating or changing the structure and function of the microbiome, it is expected to provide new strategies and means for the prevention and treatment of these diseases.
Project curriculum design research topics:
Microbiome based immune regulation and disease treatment
Research purpose:
To explore the molecular mechanisms and signaling pathways of the interaction between microbiome and immune system, and to provide theoretical basis and molecular targets for microbiome regulation of immune-related diseases. To develop novel microbiome intervention techniques and formulations to provide new methods and means for the treatment of immune-related diseases. To evaluate the efficacy and safety of microbiome intervention in the treatment of immune-related diseases, and to provide scientific basis and optimization plan for the clinical application of microbiome intervention.
Research content:
1. The relationship between microbiome and infectious diseases and intervention strategies. This content aims to analyze the impact of different types of infectious diseases (such as bacterial infections, fungal infections, parasitic infections, etc.) on the host microbiome, as well as the resistance of the host microbiome to infectious pathogens, screen functional strains or engineered bacteria that have antibacterial or enhanced immunity against infections, and evaluate their efficacy in the treatment of infectious diseases.
2. The relationship between microbiome and autoimmune diseases and intervention strategies. This content aims to analyze the influence of different types of autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, etc.) on the host microbiome, as well as the regulatory role of the host microbiome on autoimmunity tolerance and autoimmune response, and screen functional strains or engineered bacteria with anti-inflammatory or immunotolerant ability. And to evaluate the therapeutic effect on autoimmune diseases.
3. The relationship between microbiome and tumor and intervention strategies. This content aims to analyze the influence of different types of tumors (such as digestive tract tumors, lung cancer, breast cancer, etc.) on the host microbiome, as well as the promotion or inhibition of the host microbiome on the occurrence, development and metastasis of tumors, screen functional strains or engineered bacteria with anti-tumor or synergistic anti-tumor immunity, and evaluate their efficacy in tumor therapy.
4. Relationship between microbiome and allergic diseases and intervention strategies. This content aims to analyze the influence of different types of allergic diseases (such as asthma, allergic rhinitis, eczema, etc.) on the host microbiome, as well as the regulatory role of the host microbiome on the allergen-induced Th2 immune response, and screen functional strains or engineered bacteria with the ability to inhibit Th2 immunity or induce Th1/Th17 immune balance. And to evaluate the therapeutic effect on allergic diseases.
Expected results:
To establish a microbiome database of patients with different types of immune-related diseases and healthy people, and reveal the molecular mechanisms and signaling pathways of microbiome interaction with the immune system.
Functional strains or engineered bacteria with immunomodulatory ability were screened to construct novel microbiome intervention techniques and preparations.
To confirm the efficacy and safety of microbiome intervention in the treatment of immune-related diseases through animal models and clinical trials, and to explore the synergistic effect and optimization of microbiome intervention with other therapeutic means.
Project highlights:
1. Adopt multi-omics methods (such as metagenomics, transcriptomics, metabolomics, etc.) to systematically analyze the microbiome characteristics of patients with different types of immune-related diseases and healthy people, and reveal the molecular mechanisms and signaling pathways of the interaction between the microbiome and the immune system.
2. Optimize and modify the microbiome to enhance its immunomodulatory ability and provide new microbial preparations for the treatment of immune-related diseases by means of functional strain screening, fecal transplanting and construction of engineered bacteria.
3. Use animal models and clinical trials to evaluate the efficacy and safety of microbiome intervention in the treatment of immune-related diseases, and explore the synergistic effect and optimization of microbiome intervention with other therapeutic means (such as drugs, chemoradiotherapy, immunotherapy, etc.).
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